In Vitro:Article Title: In vitro to human in vivo translation - pharmacokinetics and pharmacodynamics of quinidine.
Article Snippet: .. 2: Drug related in vitro ADME data used for quinidine and its main metabolite (3-OH quinidine) in the simulation Compound Module Model utilized Model parameters Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Absorption ADAM model for oral solid formulations Solid formulation where applicable Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski Quinidine correction Metabolism Enzyme kinetics HLM based data for 3-hydroxylation and N-oxidation Elimination Renal clearance Typical renal clearance for a 20- to 30- year-old healthy male (L/h) Transport Transporter kinetics on intestinal Jmax/Km for the apical efflux ABCB1 transporter absorption Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski 3-OH quinidine correction Metabolism In vivo clearance Default Simcyp CLpo value used Elimination Renal clearance Typical renal clearance for a 20- to-30 year-old healthy male (L/h) Altex 30, 3/13312 Observed vs. predicted graph and goodness of prediction measures. ..
Binding Assay:Article Title: In vitro to human in vivo translation - pharmacokinetics and pharmacodynamics of quinidine.
Article Snippet: .. 2: Drug related in vitro ADME data used for quinidine and its main metabolite (3-OH quinidine) in the simulation Compound Module Model utilized Model parameters Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Absorption ADAM model for oral solid formulations Solid formulation where applicable Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski Quinidine correction Metabolism Enzyme kinetics HLM based data for 3-hydroxylation and N-oxidation Elimination Renal clearance Typical renal clearance for a 20- to 30- year-old healthy male (L/h) Transport Transporter kinetics on intestinal Jmax/Km for the apical efflux ABCB1 transporter absorption Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski 3-OH quinidine correction Metabolism In vivo clearance Default Simcyp CLpo value used Elimination Renal clearance Typical renal clearance for a 20- to-30 year-old healthy male (L/h) Altex 30, 3/13312 Observed vs. predicted graph and goodness of prediction measures. ..
Clinical Proteomics:Article Title: In vitro to human in vivo translation - pharmacokinetics and pharmacodynamics of quinidine.
Article Snippet: .. 2: Drug related in vitro ADME data used for quinidine and its main metabolite (3-OH quinidine) in the simulation Compound Module Model utilized Model parameters Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Absorption ADAM model for oral solid formulations Solid formulation where applicable Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski Quinidine correction Metabolism Enzyme kinetics HLM based data for 3-hydroxylation and N-oxidation Elimination Renal clearance Typical renal clearance for a 20- to 30- year-old healthy male (L/h) Transport Transporter kinetics on intestinal Jmax/Km for the apical efflux ABCB1 transporter absorption Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski 3-OH quinidine correction Metabolism In vivo clearance Default Simcyp CLpo value used Elimination Renal clearance Typical renal clearance for a 20- to-30 year-old healthy male (L/h) Altex 30, 3/13312 Observed vs. predicted graph and goodness of prediction measures. ..
Formulation:Article Title: In vitro to human in vivo translation - pharmacokinetics and pharmacodynamics of quinidine.
Article Snippet: .. 2: Drug related in vitro ADME data used for quinidine and its main metabolite (3-OH quinidine) in the simulation Compound Module Model utilized Model parameters Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Absorption ADAM model for oral solid formulations Solid formulation where applicable Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski Quinidine correction Metabolism Enzyme kinetics HLM based data for 3-hydroxylation and N-oxidation Elimination Renal clearance Typical renal clearance for a 20- to 30- year-old healthy male (L/h) Transport Transporter kinetics on intestinal Jmax/Km for the apical efflux ABCB1 transporter absorption Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski 3-OH quinidine correction Metabolism In vivo clearance Default Simcyp CLpo value used Elimination Renal clearance Typical renal clearance for a 20- to-30 year-old healthy male (L/h) Altex 30, 3/13312 Observed vs. predicted graph and goodness of prediction measures. ..
In Vivo:Article Title: In vitro to human in vivo translation - pharmacokinetics and pharmacodynamics of quinidine.
Article Snippet: .. 2: Drug related in vitro ADME data used for quinidine and its main metabolite (3-OH quinidine) in the simulation Compound Module Model utilized Model parameters Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Absorption ADAM model for oral solid formulations Solid formulation where applicable Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski Quinidine correction Metabolism Enzyme kinetics HLM based data for 3-hydroxylation and N-oxidation Elimination Renal clearance Typical renal clearance for a 20- to 30- year-old healthy male (L/h) Transport Transporter kinetics on intestinal Jmax/Km for the apical efflux ABCB1 transporter absorption Binding B/P (blood-to-plasma ratio), Default Simcyp values used fu (fraction unbound in plasma) Distribution Minimal PBPK model Poulin and Theil method with the Bierezhkovski 3-OH quinidine correction Metabolism In vivo clearance Default Simcyp CLpo value used Elimination Renal clearance Typical renal clearance for a 20- to-30 year-old healthy male (L/h) Altex 30, 3/13312 Observed vs. predicted graph and goodness of prediction measures. ..
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